Using Fuzzy logic to Adjust Plasma Concentration Based on a Two-compartment Pharmacokinetic Model

摘要：

　　In this paper,a closed-loop control system was developed using fuzzy logic to adapt the parameters ofa pharmacokinetic (PK) model.The system is based on a two-compartment PK model with first-order rate process of oral administration.The fuzzy logic adaptation scheme uses the error and the change in error as the input variables.The output variable of the fuzzy controller is the scaling factor to adjust the PK parameter.The fuzzy controller adjusted the real situation concentration to the reference value derived from the parameters of population mean data according to the established rule-base.The simulation results show that the controller provides good performance to adjust the concentration with the reference values.

关键词： fuzzy logic fuzzy controller pharmacokinetic model parameter adaption

作者: Lei Zhao Xinling Shi Yufeng Zhang Yajie Liu

作者单位: School of Information Science and Engineering, Yunnan University, Kunming, China;School of Science, School of Information Science and Engineering, Yunnan University, Kunming, China School of Information Science and Engineering, Yunnan University, Kunming, China;Department of Medic

会议类型: 国际会议

会议名称: 2013 2nd International Conference on Systems Engineering and Modeling(ICSEM-13)(2013年第二届系统工程与建模国际会议)

会议地点: 北京

会议语种:英文

页码: 671-674

在线出版日期: 2013-04-19（万方平台首次上网日期，不代表论文的发表时间）