Study of Physical Properties of Poly (vinyl alcohol)-Collagen Hydrogels Using a Response Surface Methodology
A novel covalent bond cross-linked poly (vinyl alcohol) (PVA)-collagen hydrogel was prepared and the physical properties were studied.The carboxyl groups were introduced into PVA through the reaction with chloroacetic acid.The EDC and NHS were used as cross-linker.The hydrogels were prepared by repeated freezing and thawing.For a better understanding of the influence of the parameters and their interaction,three factors were investigated by a response surface methodology.The physical properties of the hydrogels were analyzed.The results indicated that the response surface models could significantly fit the response values.Moreover,comparing with the single factor,the interactions between factors had more obvious effects to the physical properties of PVA-Collagen hydrogels.After the analysis of factors influences and investigation of the data and trends,the structure of the hydrogels might be the driving force of the different physical behaviors.
poly (vinyl alcohol) collagen hydrogels physical properties Response Surface Methodology
Yang Hu Hai Lin Lan Liu Weihua Dan
Department of Biomass Chemistry and Engineering, Sichuan University, Chengdu 610065, China National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China
国际会议
太原
英文
170-176
2013-03-22（万方平台首次上网日期，不代表论文的发表时间）