Effects of four mesostructures on their drug release properties
Five ordered mesoporous materials,SBA-1,MCM-48,SBA-7,MCM-41 and SBA-15,were prepared and tested as mesophase drug delivery systems with an anti-inflammatory drug,ibuprofen.The results of these mesostructures on in vitro ibuprofen delivery indicated that the mesoporous materials with cage-like structure,SBA-1 and SBA-7,had unfavorable load and release properties.MCM-48 also showed fast release rate due to its opening channel.However,the hexagonal mesostructure in MCM-41 and SAB-15 was advantageous for extending drug release rate although a little difference existed between them.Compared with commercial ibuprofen capsule,the release system based on MCM-41 materials displayed the drug efficacy in a longer time.
sol-gel diffusion mesostructure drug delivery ibuprofen
Wei Zeng
College of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin 300457, PR China
国际会议
太原
英文
125-128
2013-01-13（万方平台首次上网日期，不代表论文的发表时间）