Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as Intermediate for Montelukast Sodium

摘要：

　　1,1-Bis(hydroxymethyl)cyclopropane was synthesized by reaction dibromoneopentyl glycol with zinc powder at mole ratio of nDG:nzinc=1∶1.05 and 80℃ (slightly reflux) for 7 hours.Under optimal conditions,yield and purity of the title compound were 87.3% and 98.67%,respectively.Dibromoneopentyl glycol was also prepared in 91.7% yield with pentaerythritol and hydrobromic acid as material and diethyl sulfate as catalyst under reflux for 10 hours.Structural characterization of 1,l-bis(hydroxymethyl)cyclopropane was conducted by IR and H-NMR.

关键词： Montelukast Sodium Intermediate 1 1-Bis(hydroxymethyl)cyclopropane Synthesis

作者: LI Shuan LI Runlai ZHANG Zhenming YE Sheng WANG Guocheng LIU Hanghang

作者单位: Jiangsu Research and Development Institute of Marine Resources, Huaihai Institute of Technology, Lia Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology,

会议类型: 国际会议

会议名称: 2012 The 2nd International Conference on Biotechnology,Chemial and Materials Engineering(第二届生物、化工和材料工程国际会议(CBCME2012))

会议地点: 厦门

会议语种:英文

页码: 7-10

在线出版日期: 2012-12-28（万方平台首次上网日期，不代表论文的发表时间）