Characterization of Synonymous Codon Usage Bias in the UL1 Gene of Duck Plague Virus
In this study,we calculated the codon usage bias in DPV CHv UL1 gene and performed a comparative analysis of synonymous codon patterns in UL1 of DPV CHv strain and other 19 reference herpesviruses.The results revealed that the synonymous codons with A and T at the third codon positon have widely usage in the codon of UL1 gene of DPV CHv.G + C compositional constraint was the main factor that determined the codon usage bias in UL1 gene.In addition,the codon usage bias ofDPV CHv UL1 gene was compared with those ofE.coli,yeast and human.There are 25 codons showing distinct usage differences between DPV and E.coli,26 codons between DPV and yeast,and 21 codons between DPV and human.Therefore,the Human expression system is more suitable for heterologous expression of the DPV UL1 gene.
duck plague virus UL1 gene codon usage bias
Lingjie Zuo Anchun Cheng Mingshu Wang
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu city, Sichuan, 611130, P.R.China ; Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University,46 Xinkang Road, Yaan, Sichuan, 625014, P.R.China ; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, Chengdu city, Sichuan, 611130, P.R.China
国际会议
厦门
英文
693-700
2012-12-28（万方平台首次上网日期，不代表论文的发表时间）