The Effects of ligustrazine on the Expression of Bax protein and Cytochrome C Following Focal Cerebral Ischemia/Reperfusion Injury in Rats

摘要：

　　AIMS:To explore gene expressions of Bax and changes of cytC releasing in the CIR hippocampus neuron; to observe the effect on CIR with ligustrazine.METHODS:According to Bannisters,we made ischemia and reperfusion models of rat,and then using ligustrazine to cure; we observed the expression changes of Bax gene in hippocampus neurons by nucleic acid in situ hybridization,detecting cytC release through Western blotting.RESULTS:Ligustrazine protect neuron by reducing neuronal apoptosis induced by CIR,and inhibiting release of cytc by releasing.

关键词： CIR ligustrazine Hippocampus hybridization in situ

作者: Qiuzhen Zhao Hua Liu Huaguang Li

作者单位: Office of Students Affairs, Hebei North University Zhangjiakou, Hebei Province, 075000, China Life Science Research Center, Hebei North University Zhangjiakou, Hebei Province, 075000,China Department of Orthopaedics, the First Affiliated Hospital of HeBei North University, Zhangjiakou,075

会议类型: 国际会议

会议名称: 2012 The 2nd International Conference on Biotechnology,Chemial and Materials Engineering(第二届生物、化工和材料工程国际会议(CBCME2012))

会议地点: 厦门

会议语种:英文

页码: 824-827

在线出版日期: 2012-12-28（万方平台首次上网日期，不代表论文的发表时间）