Tumstatin 7 Peptide affect Biological Activity of B16 melanoma Cell
To study the effect of biological activity of Tumstatin 7 peptide on the cell proliferation and apoptosis of B 16 melanoma.Tumstatin 7 peptide was synthesized and its purity is 98.4532% by high-performance liquid chromatography.The effect of 7 peptide on B16 melanoma was observed by MTT,cell growth curve,the observation of the transmission electron microscope (TEM).7 peptide can significantly inhibit B16 melanoma cell proliferation,showing dose-and time-dependent.Its IC50 was 72.53 μg/ml.The morphology ofB 16 melanoma cell was obviously changed by TEM,such as karyopyknosis and apoptotic bodies.So7 peptides can inhibit the proliferation of melanoma cells and promote melanoma cells apoptosis.It will be of great potential value to melanoma treatment.
Tumstatin Cell apoptosis melanoma cell proliferation
Shujing Wang Jia Liu Fei Wang Shan Jiang Ning Chen Lin Liu Ying Zhao Xiaodan Zhang
College of pharmacy, Harbin University of Commerce, Harbin, Heilongjiang, China, 150076
国际会议
厦门
英文
915-918
2012-12-28（万方平台首次上网日期，不代表论文的发表时间）