The study in the toxic effects of the material bisphenol A at long time exposure
Bisphenol a (BPA),is a chemical that has been used for more than 40 years in the manufacture of many hard plastic food containers such as baby bottles and reusable cups and the lining of metal food and beverage cans,including canned liquid infant formula.Therefore,it is very necessary to study its health risk and ecological risk.In this paper,four typical estrogen acceptor genes (AHR1,ESR1,VTG1 and VTG3) in female zebrafish liver were studied to assess the low dose and chronic effects of bisphenol A (BPA),with the method of quantitative real-time RT-PCR,and the ability of self regulation and repair of these genes were also discussed.The results showed that these genes could be induced even at 15 ug/L BPA,and VTG 3 was the most sensitive gene.VTG 3 and VTG 1 had obvious self repair and adjustment ability when BPA risk was removed.No monotonic dose-effect relationships of BPA were also found at this study.
quantitative real-time RT-PCR bisphenol a estrogen receptor genes chronic exposure
Zheng-hua Duan Hua Wang Xiaohao Zhang Ning-tao Li
School of Environmental Science and Safety Engineering, Tianjin University of Technology,Tianjin, 30 Tianjin Entry-Exit Inspection Quarantine Bureau, Technical Center for Safety of Industrial Products,
国际会议
厦门
英文
1010-1014
2012-12-28（万方平台首次上网日期，不代表论文的发表时间）