Design, Synthesis and biological activity evaluation of novel N-Acylation substituted isatin derivatives

摘要：

　　Isatin,an endogenous compound existent in many organisms,shows a wide range of biological activities.In this paper,we like to report the design and synthesis of several isatin derivatives through the acetalization and N-Acylation.Six newly synthesized compounds were characterized on the basis of 1H NMR,and those compounds were determined using two different human cancer cell.Anti-cancer activity showed those compounds IC50<50 μm.

关键词： Isatin derivatives N-Acylation reaction anti-cancer activity

作者: Bin Zeng Xiaohua Zhu

作者单位: School of life science, Jiangxi Science & Technology Normal University, Nanchang, China, 330013 Jiangxi Science & Technology Normal University, Nanchang, China, 330013

会议类型: 国际会议

会议名称: 2nd International Conference on Advanced Materials and Engineering Materials(第二届先进材料与工程材料国际会议)(ICAMEM2012)

会议地点: 北京

会议语种:英文

页码: 34-37

在线出版日期: 2012-12-16（万方平台首次上网日期，不代表论文的发表时间）