Perchlorate-Induced Oxidative Stress in Isolated Liver Mitochondria Responsible for Apoptosis in Primary Cultured Hepatocytes

摘要：

　　The Perchlorate (ClO4-) has been manifested that it could inhibit thyroid hormone synthesis.However,little is known about the effects of the Perchlorate on cell and organelle.To investigate whether Perchlorate exposure causes cytotoxicity in fish by inducing oxidative stress,the primary cultured hepatocytes isolated from Carassius auratus and were incubated with different concentrations (0-10 mmol L-1) of the Perchlorate at 25℃ for 12 h in vitro.In addition,to elucidate the precise mechanism of the Perchlorate induced oxidative stress in mitochondria responsible for toxicity in hepatocytes,isolated liver mitochondria were incubated with different concentrations (0-1000 μmol L-1) of the Perchlorate.

关键词： Perchlorate Oxidative stress Mitochondria Hepatocytes Apoptosis

作者: Xiao-Hu Zhao Pei-Jiang Zhou Xiu Chen

作者单位: School of Resources and Environmental Sciences,Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory,Wuhan University,Wuhan 430079,China

会议类型: 国际会议

会议名称: 3rd International Conference on Pollution Ecology(第三届污染生态学国际会议(3rd ICPE))

会议地点: 天津

会议语种:英文

页码: 27-27

在线出版日期: 2012-11-06（万方平台首次上网日期，不代表论文的发表时间）