ACTIVE DRUG MONITORING USING ELECTRONIC HEALTH RECORDS:A CASE-CONTROL STUDY OF AZITHROMYCIN-INDUCED QT PROLONGATION
Non-antiarrhythmic drugs can induce QT prolongation, which can cause serious arrhythmias such as Torsade de pointes. Azithromycin, a macrolide antibiotic, has been proposed as a cause of QT prolongation in several case reports. We conducted a case-control study to evaluate the possible causal relationship between the two using electronic health record (EHR) data. Clinical data on 13,670 cases and 46,674 controls were extracted from the EHRs of a tertiary teaching hospital in Korea. The adjusted odds ratio was 1.68 and the 95% confidence interval was 1.22–2.33. Using moxifloxacin, the most commonly used positive control in clinical cardiac repolarization studies, the result was positive. Therefore, our results bolstered the possible association of azithromycin and QT prolongation. EHR represents a potentially useful data resource for active surveillance systems.
Azithromycin QT prolongation Long QT syndrome QTc interval Electronic Health record
Dukyong Yoon Man Young Park Eun Kyoung Ahn Rae Woong Park
Department of Biomedical Informatics, Ajou University School of Medicine,Suwon, Republic of Korea
国际会议
The 7th Asia Pacific Association for Medical Informatics Conference(第七届亚太医药信息学大会(APAMI2012))
北京
英文
1-3
2012-10-24（万方平台首次上网日期，不代表论文的发表时间）