Absorption Enhancing Effect of Sodium Dodecyl Sulfate on Metformin Hydrochloride in Rat Colon
The aim of this study was to observe the absorption enhancing effect of sodium dodecyl sulfate on metformin hydrochloride in colon of rat.Using in vivo intestinal loop model in rat while the ileum was took as blank group and colon as the experiment groups with different concentration of sodium dodecyl sulfate (1%,2%,4%).The colon/ileum ratio of the absorption rate constant of metformin hydrochloride was evaluated through calculating the residual dose of circulating solution in presupposition time points.Intergroup absorption rate constant and the rising percent of the absorption rate constant were different significantly (P<0.05).The absorption rate constant of colon were-0.22±0.03,-0.37±0.06,-0.89±0.09,-0.86±0.05 μg·h-1 ·cm-1 (n=6) and the rising percent of the constant absorption value were 68.66 ± 8.28%,304.88 ± 28.76%,293.75 ± 33.19% (n =6),respectively.The result showed that the absorption of metformin hydrochloride was increased with the concentration of sodium dodecyl sulfate.However,the absorption rate constant reached maxium when the concentration of sodium dodecyl sulfate was 2%,this may be because the circulating metformin hydrochloride solution could be more viscous which affect the absorption of metformin hydrochloride when sodium dodecyl sulfate was raised.In conclusion,the absorption of metformin hydrochloride can be promoted by sodium dodecyl sulfate in the colon of rat and this can provide biophamaceutics data for novel pharmaceutical preparation.
Colon Metformin hydrochloride Sodium dodecyl sulfate
Dongdong Jing Yu Liu Ruoyu Liu Hua Fan Guofeng Li Longquan Shao
Department of Pharmacy,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China Anhui Provincial Institute of Materia Medica,Hefei 230022,China Department of Stomatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China Department of Stomatology,The Peoples Hospital of Sanshui district,Foshan 528100,China
国际会议
景德镇
英文
426-430
2012-10-15（万方平台首次上网日期，不代表论文的发表时间）