Rapid Analysis of the Main Components of Glycyrrhizae uralensis Fisch.by UPLC/Q-TOF-MS
A rapid method for analysis of the main components of Radix Glycyrrhizae (RG) was developed using ultra-performanceliquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS).Previous study demonstrated that RG had antivirus,antioxidant,anti-tumor and other bioactivities.The separation analysis was performed on Waters Acquity UPLC system and the accurate mass of molecules and their fragment ions were determined by Q-TOF MS.Fourty compounds including triterpenoid saponins,flavonoid glycosides and flavonoid aglycones,coumarins,were identified and tentatively deduced on the basis of their element compositions,MS/MS data and relevant literatures.The results demonstrated that triterpenoid saponins,flavonoid glycosides and flavonoid aglycones were the main constituents of RG.Furthermore,an effective and rapid pattern was established allowing for comprehensive and systematic characterization of the complex samples.
UPLC/Q-TOF MS/MS Radix Glycyrrhizae Rapid Analysis
Zhongfeng Shi Yifan Feng Wen Rui Liang Wang Xiaomei Zhang Liang Han
Central Laboratory, GuangDong Pharmaceutical University, Guangzhou 510006, China Industrial Office, GuangDong Pharmaceutical University, Guangzhou 510006, China
国际会议
昆明
英文
269-272
2012-10-12（万方平台首次上网日期，不代表论文的发表时间）