Spectrophotometric determination of kryptofix 2.2.2 using TCNQ
The interactions of the electron donors kryptofix (K-222) with 7,7,8,8-Tetracyanoquino-dimethane (TCNQ) were studied spectrophotometrically in aceton/water at several temperatures.The UV-vis spectra of the formed molecular charge transfer (CT) complexes were recorded.The molecular structures of the CT-complexes were independent of the position of the amino group on the K-222 and were formulated as (K-222)(TCNQ).A spectrophotometric method for determination of K-222 was developed and validated for the quantitative analysis ofK-222 in the radiopharmaceuticals.With an internal standard,the limit of quantitation for K-222 was 2 ug/ml.This is so far the most facile method for the determination of K-222.Excellent linearity (RSQ =0.9997) was obtained over the range of 2.0-31 ug/ml.Good precision and accuracy were also observed.The method is amenable to the validation of radiosynthetic methods.
Kryptofix 2.2.2 Spectrophotometry TCNQ
Mu-Yi He Li-Quan Sun Ai-Qin Luo
School of life science, Beijing Institute of Technology, Beijing 100081, China
国际会议
昆明
英文
1156-1159
2012-10-12（万方平台首次上网日期，不代表论文的发表时间）