The study of terminated PEG maleimide synthesis and modification of hemoglobin
There is a worldwide increased demand for blood transfusions.In Third World countries is not sufficient due to the spreading of infections,such as HIV.The current generation of so-called hemoglobin-based oxygen carders (HBOCs) comprise hemoglobins from different species (human and bovine) that have been chemically modified to improve structural stability.However,some adverse effects such as hypertension,myocardial infarction and acute kidney failure have been found in several clinical trials.The exact factors leading to the symptoms are still uncertain,but high molecular weight was believed to play an important role.Therefore,Maleimide polyethylene glycol 5000 monomethyl ether(mPEG-MAL) as Hemoglobin(Hb) modifier can change the Molecular weight of Human placenta hemoglobin effectively.In addition,hemoglobin weight could be severely controlled by changing the amount of the sulfhydryl modifier and mPEG-MAL,so as to achieve the demand of the people of different molecular weight.
PEGylation hemoglobin (Hb) mPEG-MAL Blood substitute modify
Lei zhang Xiang Wang Donglai Qi
Tianjin Polytechnic University,school of environmental and chemical engineering Tianjin,300387,China
国际会议
沈阳
英文
1022-1025
2012-09-26（万方平台首次上网日期，不代表论文的发表时间）