Application of Humic Substances in Medicine:Basic Studies to Assess Pro-and Anticoagulant Properties of Humic Acids

摘要：

　　This study was performed in order to evaluate the dose-dependent effect of different humic acid (HA)preparations on blood coagulation.Using the thrombelastographic method we examined HA from Altteich Peat (Eastern Saxony,Germany),sodium humate from an ombrotrophic mire in Mecklenburg-Western Pomerania,Germany,and the IHSS Reference HA from Waskish Peat (Minnesota,USA).The results revealed a strikingly bimodal behaviour of the tested HA:at high concentrations (250-1,000 μg/mL) they prolonged the reaction time,i.e.,the period of time necessary until the beginning of clot formation,by two-to twelve-fold (anticoagulant effect),however at low concentrations (0.9-31.3 μg/mL) they tended to reduce the reaction time by an average of 25% (procoagulant effect).

关键词： Bimodal effect Blood coagulation Humic substances Thrombelastography

作者: H.P.Kl(ǒ)cking R.Kl(ǒ)cking

作者单位: Friedrich Schiller University Jena,Institute of Pharmacology and Toxicology/Working Group Erfurt,c/o Research Institute for Process Engineering,Peat and Natural Products,Zittau/G(o)rlitz University of

会议类型: 国际会议

会议名称: the 16th Meeting of the International Humic Substances Society (第十六届国际腐殖物质学会大会(IHSS 16))

会议地点: 杭州

会议语种:英文

页码: 624-626

在线出版日期: 2012-09-09（万方平台首次上网日期，不代表论文的发表时间）