Hierarchical Modular Structure in Gene Coexpression Networks
Network module (community) structure has been a hot research topic in recent years.Many methods have been proposed for module detection and identification.Hierarchical structure of modules is shown to exist in different kinds of biological networks.Compared to the module identification methods,less research is done on the hierarchial structure of modules.In this paper,we propose a method for constructing the hierarchical modular structure in networks based on the extended random graph model.Statistical tests are applied to test the hierarchial relations between different modules.We give both artificial networks and real data examples to illustrate the performance of our approach.Application of the proposed method to yeast gene co-expression network shows that it does have a hierarchical modular structure with the modules on different levels corresponding to different gene functions.
Shuqin Zhang
Center for Computational Systems Biology School of Mathematical SciencesFudan UniversityShanghai, 200433, China
国际会议
6th International Conference on Systems Biology (第六届国际系统生物学会议)(ISB2012)
西安
英文
118-124
2012-08-19（万方平台首次上网日期，不代表论文的发表时间）