Dynamic miRNA-TF-mRNA circuits in mouse lung development
Genes,transcription factors (TF),microRNAs (miRNA) are well-known to have important regulating roles in dynamic biological processes.In the last years,many studies have been devoted to the elucidation of transcriptional or posttranscriptional regulating activities of TFs or miRNAs,respectively.However,very limited attempts have been made to consider the dynamic characteristics of miRNA-TF-mRNA circuits,which are the biological network motifs considering miRNAs,TFs and genes as a whole in the complicated biological procedures like mouse lung development.Here we propose to mine miRNA-TF-mRNA circuits related to the mouse lung development by integrating TF-mRNA,miRNA-mRNA,TFmiRNA,and time-course expression data,and to further analyze the variations of these circuits in different stages of the lung development.To our best knowledge,this is the first time to take transcriptional and post-transcriptional information together to describe the mouse lung development.Our preliminary results show that miRNA-TF-mRNA circuits vary in different stages of the lung development and play different roles.
miRNA-TF-mRNA circuit mouse lung development miRNA mRNA TF
Xinghuo Ye Juan Liu Fang-Xiang Wu
School of Computer Wuhan University Wuhan 430072, China Division of Biomedical Engineering University of Saskatchewan Saskatoon, SK S7N 5A9, Canada
国际会议
6th International Conference on Systems Biology (第六届国际系统生物学会议)(ISB2012)
西安
英文
256-262
2012-08-19（万方平台首次上网日期，不代表论文的发表时间）