Anti-clustering of circadian gene expression in mouse liver genome
Circadian regulatory system is an evolutionarily ancient biological system.Its prevalence in life kingdoms suggests it has fundamental role in life processes.Although genomic scale of circadian gene expression has been found in various species from cyanobacteria to mammalians,transcriptional patterns and mechanisms of global circadian gene regulation have not yet been revealed.Using high resolution temporal profiling of mouse circadian gene expression,we show that contrary with previously demonstrated clustering tendency of functionally related genes in mammalian genomes,circadian regulated genes display anti-clustering propensity in mouse liver.This unique property does not conform to the notion of domain-wide coordinated gene regulation dictated by acetyl modifications,which is recently identified as a hallmark of circadian regulation.These results suggest that global circadian regulation in mouse liver might involve other structural chromosome interactions irrelevant with clustering regulation.
anti-clustering clustering circadian global transcriptional pattern gene expression
Bin Kang Yuan-yuan Li Yi-xue Li
Shanghai Center for Bioinformation Technology Shanghai 200235, China
国际会议
6th International Conference on Systems Biology (第六届国际系统生物学会议)(ISB2012)
西安
英文
273-279
2012-08-19（万方平台首次上网日期，不代表论文的发表时间）