Comparative analysis of protein-coding genes and long non-coding RNAs of prostate cancer between Caucasian and Chinese populations
Prostate cancer is one of the most important public health problems in developed countries.To date,a systematic understanding of the pathogenesis of prostate cancer is still lacking.In this work,we identified differentially expressed protein-coding genes and long non-coding RNAs (lncRNAs) between normal and cancer tissues based on a recent RNA-seq study from Caucasian population.We then investigated the relationship between differentially expressed genes and lncRNAs.Furthermore,based on a recently published prostate cancer study on Chinese population,we identified differentially expressed genes between Caucasian and Chinese populations to investigate racial difference.Moreover,for the first time,we compared the correlation of lncRNA-gene across populations.In the end,a lot of differentially expressed genes and lncRNAs were identified.Our results revealed that most of the lncRNA-gene pairs were positively correlated especially for the lncRNA-host gene pairs,indicating the probable mechanism of lncRNA.And 320 genes were differentially expressed in prostate cancer across populations,which may help us to investigate the ethnic differences of prostate cancer.In addition,our results suggested that lncRNAs regulate genes in different manners across populations.Our findings may help understand molecular events underlying prostate cancer development.
transcriptome long non-coding RNAs prostate cancer
Fu-Yan Hu Xing-Ming Zhao Nelson L.S. Tang Yan Zhang Luonan Chen
Department of Mathematics,Institute of Systems Biology,Shanghai University,Shanghai 200444,China Institute of Systems Biology,Shanghai University,Shanghai 200444,China Department of Chemical Pathology,Faculty of Medicine,The Chinese Universityof Hong Kong,Hong Kong SA Key Laboratory of Systems Biology,Shanghai Institutes forBiological Sciences,Chinese Academy of Scie
国际会议
6th International Conference on Systems Biology (第六届国际系统生物学会议)(ISB2012)
西安
英文
291-296
2012-08-19（万方平台首次上网日期，不代表论文的发表时间）