ppiPre - an R package for predicting protein-protein interactions

摘要：

　　Since the existing experimental techniques for identifying protein-protein interactions (PPIs) are expensive and time-consuming,and the results are incomplete and/or noisy,developing computational methods for effectively predicting PPIs is of great importance.Therefore,we develop the R package ppiPre,which predicts PPIs using heterogeneous data sources,including Gene Ontology (GO) annotations,Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations and topological properties of the PPI network.ppiPre supports up to 20 species and provides useful functions for predicting PPIs and calculating semantic and topological similarities between proteins.ppiPre is open source and freely available from http://cran.r-project.org/web/packages/ppiPre).

关键词： protein-protein interactions prediction semantic similarity network topology R

作者: Yue Deng Lin Gao

作者单位: School of Computer Science and Technology,School of Software Engineering Xidian UniversityXi’an, Chi School of Computer Science and Technology Xidian UniversityXi’an, China

会议类型: 国际会议

会议名称: 6th International Conference on Systems Biology (第六届国际系统生物学会议)(ISB2012)

会议地点: 西安

会议语种:英文

页码: 333-337

在线出版日期: 2012-08-19（万方平台首次上网日期，不代表论文的发表时间）