Effects of Asian Sand Dust on Allergic Airway Inflammation in Mice
There is no experimental study demonstrating the effects of airborne Asian sand dust (ASD) on allergic lung eosinophilia.The organic substances adsorbed onto ASD collected from the atmosphere of Iki-island in Japan were excluded by heat treatment at 360℃ for 30 min.The effects of ASD or heated-ASD (H-ASD) towards allergic lung inflammation were compared in murine lungs to investigate the role of organic substances.ICR mice were administrated with the two kinds of ASD and/or ovalbumin (OVA) intratracheally four times at 2-week intervals.ASD and H-ASD enhanced eosinophil recruitment induced by OVA in the the airway.ASD and H-ASD synergistically increased Th2 cytokines-interleukin-13 (IL-13),eosinophil-relevant cytokine and chemokine,such as IL-5,and monocyte chemotactic protein-3 (MCP-3) induced by OVA in whole lung lavage fluid.The enhancing effects were much greater in ASD than in H-ASD.These results suggest that the aggravated lung eosinophilia in ASD is due to activation of a Th2-associated immune response and microbial materials could be participating in this phenomenon.
Asian sand dust allergen lung eosinophilia murine
Takamichi Ichinose Miao HE Seiichi Yoshida Rie Yanagisawa Hirohisa Takano Guifan Sun
Department of Health Sciences,Oita University of Nursing and Health Sciences,Japan Pathophysiology Research Team,National Institute for Environmental Studies,Japan Department of Environmental and Occupational Health,China Medical University
国际会议
Conference on Environmental Pollution and Public Health (2012年环境污染与大众健康学术会议(CEPPH2012))
上海
英文
17-19
2012-08-09（万方平台首次上网日期，不代表论文的发表时间）