Preparation and Characterization of Chitosan-Poly(MA-PEG400-SA)Nanoparticles as Drug Carrier

摘要：

　　In order to prepare chitosan-based nanoparticles for drug delivery,we synthesis chitosan-poly(methacryloyl polyethylene glycol succinic acid,MA-PEG400-SA) nanoparticles in aqueous solution via template polymerization.The structure of the chitosan-poly(MA-PEG400-SA)nanoparticles was characterized by FT-IR spectra,and the particles size and surface charge were analyzed by zetasizer,respectively.The average size of chitosan-poly(MA-PEG400-SA)nanoparticles was approximate 325 nm,and the surface charge was 33mv.Using hydrophilic drug 5-FU as the model drug,the drug loading efficiency was about 6%.In the further study,we will optimize the synthesis conditions and study on the drug release properties of the nanoparticles.

关键词： Chitosan Poly(MA-PEG400-SA) Polymerization Nanoparticles Drug Carrier

作者: Dan Zhang Fei Qiu Yong Diao

作者单位: Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, Fujian, China;Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou 362021,Fujian, China

会议类型: 国际会议

会议名称: the 2012 International Conference on Frontiers of Nanoscience and Technology(2012年纳米科学与技术国际会议(ICFNST 2012))

会议地点: 香港

会议语种:英文

页码: 39-42

在线出版日期: 2012-07-26（万方平台首次上网日期，不代表论文的发表时间）