Preparation of cortex moutan nanoparticles and its microscopic characteristics and physicochemical properties
Objective In order to increase the Paeonol dissolution and content,cortex moutan were smashed into nanoparticles,and the dissolution and content were compared by microscopy before and after super-micro-particle pulverization.Methods Super-micro-particle pulverization and general grinding were used to broke Cortex moutan into particles.The microscopic morphous characteristics of the before-and after-ultra-disintegration particles were compared by microscopy.Methods of HPLC was used to determine the content and dissolution of Paeonol with different grinding conditions.Methods of precipitation and funnel way were used to examine the stability and fluidity of cortex moutan nano-particles.Results Cortex moutan powder after super-micro-particle pulverization appears sphere or like-sphere,and its average size is 200nm~300nm.After the superfine grinding Paeonol dissolution increases 76.19% in comparison with without nano pulverization.The nanoparticle rest angle isθ=33°.The precipitation ratio of Cortex moutan powder with general grinding is 0.28 at 24h,and the precipitation ratio of its nano-power has been to 0.98 at 60min.Conclusion Paeonol dissolution,stability and fluidity of Cortex moutan nanoparticles were improved greatly and this nanoparticles is beneficial to industrial production for traditional Chinese medicine.
Cortex moutan Paeonol super-micro-particle pulverization dissolution stability fluidity
Cui Yu-jia Wang Wei-guo Li Peng Zhao Yong-liang Gu Ya-nan Meng Tian-tian Ding Jin-ju Zhang Peng Jia Ke
Bioengineering College, Henan University of technology, Zhengzhou, Henan 450001, China
国际会议
香港
英文
54-57
2012-07-26（万方平台首次上网日期，不代表论文的发表时间）