Capsaicin Injectable In-situ Forming Gels

Capsaicin exhibits the analgesic and anti-inflammatory activities,therefore it is interesting to apply this natural active compound for periodontitis treatment by local drug delivery system such as intra-canal route.Capsaicin in-situ forming gels were prepared in this research work.The viscosity,gel forming property and capsaicin release were evaluated.30%W/W eudragit RS 30D in N-methylpyrrolidone (NMP) employed as gel base was physicaly stable after sterilization with autoclaving and exhibited the in-situ forming gel property.This gel base was still clear when capsaicin was less than 0.0094%w/w.When the system contacted with phosphate buffer pH 6.8 the turbid gel was appeared rapidly at the interface.Viscosity of system depended on the amount of eudragit RS 30D.The rheology of systems was newtonian flow and amount of capsaicin tincture did not affect the rheological behavior.The release rate and amount of capsaicin release form gels were lower than those of capsaicin solution.The sustainable release of capsaicin could be obtained from the developed in-situ forming gel.
Capsaicin eudragit RS 30D in-situ forming gel injection
Phaechamud T Tuntarawongsa S
Department of Pharmaceutical Technology,Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand
国际会议
香港
英文
103-106
2012-07-26(万方平台首次上网日期,不代表论文的发表时间)