The stability study of Nifeviroc-loaded microemulsions
The objective is to study the stability of Nifeviroc-loaded microemulsions (Nifeviroc-MEs).The dilution stability of Nifeviroc-MEs with different loading capacity (0.1%,0.2%,0.3%) was tested by change of mean size,pH and appearance.The centrifugal stability was evaluated by comparing the mean size of Nifeviroc-MEs and dilutions before and after high-speed centrifugation for 30,60,120 min at 10000 rpm.The storage stability was evaluated by the change of appearance,the mean size,PDI and the retention rate of Nifeviroc in the ME.The pH,appearance,size analysis and retention rate results showed the Nifeviroc-MEs had good dilution,centrifugal stability and good storage stability without light.
Nifeviroc microemulsion dilution stability centrifugal stability storage stability
Hongjing Zhou Fang Tian Qiang Xia Li Chen Weihua Li Xuncheng Ding
School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096,China;Sta Shanghai Institute of Planned Parenthood Research, Shanghai 200032,China Shanghai Targetdrug co., Ltd., Shanghai 200032,China
国际会议
香港
英文
277-280
2012-07-26（万方平台首次上网日期，不代表论文的发表时间）