Ultrasound Modulated Release of Lysozyme from Microcapsules of PLA-b-PEG Copolymer

摘要：

　　In this paper,ultrasound (US) was employed as a non-invasive and on-demand control approach to modulate the release behavior of poly(lactic acid)-b-poly(ethylene glycol) (PELA) microcapsules containing lysozyme (Lyz).Release kinetics of the Lyz was monitored by UV spectrophotometer.It was found that US can trigger release of the encapsulated Lyz from the PELA microcapsules.US actuation had a slight influence on the enzymatic activity,but not significant.Based on the results obtained,an irreversible release mechanism under US was proposed.The irreversible release of Lyz from the PELA microcapsules was attributed to the physical disruption of microcapsule by US.

关键词： Ultrasound-responsive Drug delivery Microcapsules PLA-b-PEG (PELA) lysozyme

作者: BAO Min ZHOU Qi-hui DONG Wen ZHANG Yan-zhong

作者单位: Laboratory of Biomimetic Materials for Regenerative Medicine, Department of Bioengineering College of Chemistry, Chemical Engineering & Biotechnology , Donghua University, Shanghai , China

会议类型: 国际会议

会议名称: 2012 International Forum on Biomedical Textile Materials (2012国际纺织生物医用材料论坛)

会议地点: 上海

会议语种:英文

页码: 3-6

在线出版日期: 2012-06-08（万方平台首次上网日期，不代表论文的发表时间）