Synthesis of Hollow Silica Nanospheres by the Intermolecular Interactions within Amphiphilic Block Copolymer Micelle Templates

摘要：

　　In this work,hollow mesoporous silica nanoparticles (HMSNs) have been successfully synthesized in a facile route using PS-b-PAA and CTAB as co-templates at room temperature.The shell thickness of the synthesized HMSNs could be tailored by changing the addition rate of the silica source,and the poperties of these nanoparticles were then characterized by using XRD,N2 adsorption-desorption analysis,TEM and UV-vis analysis.Furthermore,Doxorubicin (DOX)-loaded HMSNs (DMSNs) show an effective drug loading and a pH-responsive drug release property.

关键词： Hollow mesoporous silica nanoparticles Amphiphilic block copolymer micelle Thickness of shell Doxorubicin Drug delivery

作者: CHENG Xiao QIU Ke-xin HU Jin-wei ZHOU Xiao-jun CHEN Meng-xia HE Chuang-long

作者单位: College of Chemistry, Chemical Engineering and Biotechnology , Donghua University, Shanghai , China

会议类型: 国际会议

会议名称: 2012 International Forum on Biomedical Textile Materials (2012国际纺织生物医用材料论坛)

会议地点: 上海

会议语种:英文

页码: 12-15

在线出版日期: 2012-06-08（万方平台首次上网日期，不代表论文的发表时间）