Preparation and Characterization of Nanofibrous Vascular Tissue Engineering Scaffolds via Phase Separation

摘要：

　　Major limitations for the development of a clinically useful small diameter tissue engineered vascular graft (TEVG) are lack of good mechanical and elastic properties,compliance mismatch,and thrombosis.In this study,porous poly(L-lactic acid) (PLLA) based vascular scaffolds were fabricated by using thermally induced phase separation (TIPS) technique,their mechanical and elastic properties were enhanced by the addition of PLCL.Furthermore,in order to improve blood patency rate,the scaffolds were crosslinked with heparin.The obtained scaffolds were characteried byscanning electron microscope (SEM),Fourier transform infrared spectroscopy (FTIR),and tensile strength testing.

关键词： Vascular Scaffold Phase separation Tissue engineering PLLA PLCL

作者: HU Jin-wei QIU Ke-xin CHENG Xiao WANG Wei-zhong MO Xiu-mei HE Chuang-long

作者单位: College of Chemistry, Chemical Engineering and Biotechnology , Donghua University, Shanghai , China

会议类型: 国际会议

会议名称: 2012 International Forum on Biomedical Textile Materials (2012国际纺织生物医用材料论坛)

会议地点: 上海

会议语种:英文

页码: 91-94

在线出版日期: 2012-06-08（万方平台首次上网日期，不代表论文的发表时间）