Fabrication of Liposome-Loaded Silk Fibroin Nanofiber Mats by Electrospinning

摘要：

　　Liposome is widely used in biomedical field owing to its remarkable ability of delivery drugs.Thus,the introduction of liposcmal drug delivery systems into tissue engineering scaffolds may result in good effect on tissue regeneration.In this study,we successfully fabricated a novel liposome-loaded SF nanofiber based on the eco-friendly method.The electrospun SF fibers were ribbon-shaped and the liposome-loaded SF nanofibers showed no obvious change compared with the pure silk fibroin nanofibers as showed by scanning electron microscopy (SEM).While the Fourier Transform Infrares (FTIR) spectra showed some difference between pure SF nanofibers and Liposome loaded SF nanofibers.Transmission electron microscopy (TEM) showed that liposome distributed on the liposome-loaded SF nanofibers.This novel liposome loaded SF nanofiber mats can be a promising biomaterial in tissue engineering and universally used in medical field.

关键词： Silk Fibroin Liposome Electrospinning Nanofiber scaffolds

作者: CUI Cheng-jun HAN Feng HE Chuang-long WU Chun-chen MO Xiu-mei WANG Hong-sheng

作者单位: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology , Donghua University, Shanghai , China

会议类型: 国际会议

会议名称: 2012 International Forum on Biomedical Textile Materials (2012国际纺织生物医用材料论坛)

会议地点: 上海

会议语种:英文

页码: 157-160

在线出版日期: 2012-06-08（万方平台首次上网日期，不代表论文的发表时间）