Identifying the Factors Influencing Formation of Nanoporous Electrospun Poly(L-lactic acid) Fibers

摘要：

　　In tissue engineering research,cell behavior can be modulated by the scaffold topography that resembles the dimensional scaleof the native extracellular matrix.To explore the cellular influence of nanopores presented on a kind of biomimicking ultrafine fibers by electrospinning,this work was firstly designed to identify some key factors that govern the formation of nanoporous morphology on a model scaffolding polymer poly(L-lactic acid) (PLLA) in electrospinning.It was found that higher solution concentrations,higher ambient humidity,lower applied voltage,andsolvents of lower boiling pointsare all in favor of forming nanopores with tailorable pore size and quantity.An underlying mechanism likely responsible for the formation of nanopores on the electrospun PLLA nanofiber was also proposed.

关键词： Nanopore Electrospinning Poly(L-lactic acid) Nanotopographical effect

作者: ZHOU Qi-hui ZHAO Shi-fang BAO Min DONG wen ZHANG Yan-zhong

作者单位: Laboratory of Biomimetic Materials for Regenerative Medicine, Department of Bioengineering, College of Chemistry,Chemical Engineering & Biotechnology, Donghua University, Shanghai, China

会议类型: 国际会议

会议名称: 2012 International Forum on Biomedical Textile Materials (2012国际纺织生物医用材料论坛)

会议地点: 上海

会议语种:英文

页码: 231-235

在线出版日期: 2012-06-08（万方平台首次上网日期，不代表论文的发表时间）