Synthesis and characterization of polyesters containing 5-fluorouracil in the main chain

摘要：

　　A series of polyesters containing 5-fluorouracil in the main chain were prepared by reacting potassium salt of 5-fluorouracil with different molecular weight ω-chloroalkyl chloroacetyl esters.The copolymers were characterized by FT-IR,1H-NMR,VPO and UV spectroscopy.The drug release profile in vitro of the copolymers were studied,the results showed prodrug could slow release 5-FU or 5-FU units in different solution,they may be likely to become potential antitumor prodrug.

关键词： 5-Fluorouracil Polyester Polymeric prodrug Antineoplastic drug

作者: Jun Chang Cheng wu Li Gang Li

作者单位: School of material science&engineering, Shenyang Ligong University, Shenyang, 110159, China

会议类型: 国际会议

会议名称: 2012 International Symposium on Polymer Composites and Polymer Testing(ISPCPT2012)(2012高分子复合材料与测试学术研讨会)

会议地点: 杭州

会议语种:英文

页码: 99-103

在线出版日期: 2012-03-23（万方平台首次上网日期，不代表论文的发表时间）