Estrogenicity of Six Typical Aqueous Pollutants
This paper studied the estrogenicity of six typical aqueous EDCs by examining their proliferation of MCF-7.These six EDCs were 17-β Estradio (E2),biphenol A (BPA),nonyl phenol (NP),di-n-butyl phthalate (DBP),hexachlorobenzene (HCB) and Cadmium (Cd).Results showed that MCF-7 proliferation was sensitive to these compounds.E2 was the most sensitive one and the effective concentration was 10-14 mol/L,while Cd was the least sensitive one and the effective concentration was 10-8 mol/L.The sensitivity of these six EDCs ranked as:E2 > BPA ≥ NP > DBP ≥ HCB > Cd.On the other hand,the cell proliferation extent of these compounds ranked as:HCB >DBP > BPA > Cd > NP ≥ E2.Very complex dose-time-response curves were observed for all six EDCs,indicating that many factors impacted the cell grow.
estrogenicity E2 BPA NP DBP HCB Cd
Guangming Zhang Lang Lang
School of Environment & Natural Resource, Renmin University of China, China Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce
国际会议
杭州
英文
455-458
2012-03-23（万方平台首次上网日期，不代表论文的发表时间）