Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization
Functionalized chitosan (CS) were widely used as drug delivery system in the chemotherapy of various disease.In this work.folate (FA) was conjugated into chitosan molecular as targeting ligand based on Schiff reaction between -NH2 group of CS and -COOH group of FA.And nanoparticles were made by emulsion method with vanillin novel cross-linking agent.The FA modified CS and its nanoparticles were characterized by Fourier transform spectroscopy (FT-IR),scanning electron microscope (SEM) and Zeta potential.SEM results confirmed the nanoparticles made from FA-CS conjugate were spherical in shape and were about 100 nm m size.Zeta potential analysis revealed that the nanoparticles were negatively charged with charge density of -7.73mV.
Folic acid chitosan vanillin chemical modification
Min Zhou Puwang Li Guang Wang Ziming Yang Zheng Peng Lingxue Kong
Agricultural Product Processing Research Institute,CATAS,Zhanjiang 524001,P.R.China Centre for Material and Fibre Innovation,Institute for Technology and Research Innovation,Deakin Uni
国际会议
太原
英文
454-457
2012-01-13（万方平台首次上网日期，不代表论文的发表时间）