ASSEMBLY OF PHARMACEUTICAL MICROPARTICLES VIA SPRAY DRYING

摘要：

　　Pharmaceutical microparticles require stringent control over their characteristics to realize their optimal therapeutic performance.Spray drying represents an elegant onestep route for the production of pharmaceutical microparticles,although a typical feature of conventional spray-dried products is the significant variation in particle properties.Hereby,the synthesis of pharmaceutical microparticles with homogeneous characteristics is possible with a micro-fluidic jet spray drying technique.This progress facilitates the methodical study on the direct relationship among formulation,production,physicochemical properties,and functionalities of these pharmaceutical microparticles via the spray-drying route.Several examples on the design and assembly of microparticles with tailor-made properties and functionalities are presented,with specific emphasis on the control over particle size,shape,microstructures,and controlled release kinetics.The underlying particle formation mechanisms and design concepts presented here are not limited to pharmaceutical components but to other functional particles as well.

关键词： pharmaceutical particles micro-fluidic jet spray drying microstructure controlled release

作者: W.Liu C.Selomulya X.D.Chen

作者单位: Department of Chemical Engineering,Monash University,VIC,3800,Australia Department of Chemical and Biochemical Engineering,College of Chemistry and Chemical Engineering,Xia

会议类型: 国际会议

会议名称: The 18th International Drying Symposium Conference(第十八届国际干燥学术大会(IDS2012))

会议地点: 厦门

会议语种:英文

页码: 1-7

在线出版日期: 2012-01-11（万方平台首次上网日期，不代表论文的发表时间）