OPTIMIZATION OF SPRAY DRYING OF PHYTOPHARMACEUTICAL PREPARATIONS FROM Bidens pilosa L.BY RESPONSE SURFACE METHODOLOGY
Spray drying is a common technique employed to obtain solid active phytopharmaceutical ingredients from medicinal plants.Bidens pilosa L.is a South American plant with proved antimalaric,antitumoral and hepatoprotective activity.The aim of this work was to optimize the drying conditions: inlet drying temperature (Tge),plant extract feed flowrate (Ws) and feed composition.The responses evaluated were total flavonoid content,residual water content,water activity,flow properties,product recovery,drying efficiency,particle size and morphology.Experimental responses were fitted to mathematical models and permit the determination of optimum processing conditions: Aerosil?:Microcrystalline Cellulose (13:37 %),Ws of 8.95 mg/min and Tge of 155.2 ?C.
microencapsulation spray drying herbal medicine Bidens pilosa L. active phytopharmaceutical ingredients dried extracts.
D.F.Cortés-Rojas C.R.F.Souza W.P.Oliveira
University of S(a)o Paulo,Faculty of Pharmaceutical Sciences of Ribeir(a)o PretoAv.do Café s/n,Ribeir(a)o Preto,P.O.B.14040901,Brazil
国际会议
The 18th International Drying Symposium Conference(第十八届国际干燥学术大会(IDS2012))
厦门
英文
1-8
2012-01-11（万方平台首次上网日期，不代表论文的发表时间）