PRECIPITATION OF PARTICLES WITH CONVECTIVE ANTISOLVENT VAPOUR

摘要：

　　Antisolvent vapour was incorporated into the single droplet drying technique resulting in the precipitation particle formation mechanism.This method allows a large number of micron size particles to be produced from a single droplet.Two types of lactose particle morphologies were observed: dendritic particles and smooth microspheres.The dendritic particles can composed of straight needle-like dendrites or short entwined dendrites.A threshold in the antisolvent humidity condition was found which forms the transition point between the two morphologies.Observation of a smooth network like structure suggests that a ‘pinched off’mechanism coupled with the effect of surface tension might be one possible route in the formation of the precipitated smooth microspheres.

关键词： Spray drying lactose antisolvent ethanol precipitation

作者: G.Q.Chin T.W.Ching S.Mansouri M.W.Woo X.D.Chen

作者单位: Department of Chemical Engineering,Monash University,Australia Department of Chemical Engineering,Monash University,Australia;Department of Chemical & Biochemical

会议类型: 国际会议

会议名称: The 18th International Drying Symposium Conference(第十八届国际干燥学术大会(IDS2012))

会议地点: 厦门

会议语种:英文

页码: 1-6

在线出版日期: 2012-01-11（万方平台首次上网日期，不代表论文的发表时间）