INSULIN PARTICLES PRODUCED BY A SUPERCRITICAL ENHANCED SPRAY DRYING PROCESS

摘要：

　　Supercritical enhanced spray drying process was employed to produce insulin submicroparticles from its ethanol/water solution.The effect of the processing conditions on the morphology,size and activity of the produced particles was investigated.Insulin particles generated from the process are generally spherical with average sizes between 0.6 and 1.1μm.FTIR,HPLC,the Lowry method and DTA-TG were implemented to investigate the activity and solvent residue of the produced particles.Results show that the ethanol content has a more sensitive effect on the particles activity than other operating factors; a high content of ethanol tends to denature the insulin particles.

关键词： carbon dioxide insulin particles supercritical fluid drying

作者: X.H.Hu L.J.Zhu S.X.Zheng J.X.Wang M.X.Jiang Y.Z.Hong Y.Z.Su H.T.Wang J.Li

作者单位: Department of Chemical and Biochemical Engineering,College of Chemistry and Chemical Engineering,National Engineering Laboratory for Green Chemical Productions of Alcohols,ethers and Esters,Xiamen University,Xiamen 361005,P.R.China

会议类型: 国际会议

会议名称: The 18th International Drying Symposium Conference(第十八届国际干燥学术大会(IDS2012))

会议地点: 厦门

会议语种:英文

页码: 1-7

在线出版日期: 2012-01-11（万方平台首次上网日期，不代表论文的发表时间）