Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine)Dendrimers and Study of Its Cytotoxic Activity

摘要：

　　The recombinant third domain of alpha-fetoprotein (AFP3D) is one of the promising vectors for targeted delivery of anticancer drugs to tumor cells.AFP3D-based conjugates with various anti-tumor agents have shown specific anti-tumor activity.The content of anti-tumor drugs in the preparation could be increased by including dendrimers-highly branched nanoparticles-into a targeted delivery system.In this study,we synthesized the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer nanoparticles and investigated its cytotoxic activity.

关键词： Alpha-fetoprotein dendrimer doxorubicin targeted delivery

作者: Kisil S.I Savvateeva L.V Chernikov V.A Danilevskiy M.I Gorokhovets N.V

作者单位: Biochemistry department I.M.Sechenov First Moscow State Medical University Moscow, Russia National Research Centre Kurchatov InstituteMoscow, Russia Research Institute of Uronephrology and Reproductive Health Care of the I.M.Sechenov First MSMU Mosc Research Institute of Molecular Medicine of the I.M.Sechenov First MSMU Moscow, Russia

会议类型: 国际会议

会议名称: 2012世界工程和技术大会

会议地点: 北京

会议语种:英文

页码: 80-83

在线出版日期: 2012-10-26（万方平台首次上网日期，不代表论文的发表时间）