Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung Cancer
Object:To explore the therapeutic effects and therapeutic mechanisms of Conditional Replication Adenovirus(CRAd) in combination with cisplatin on lung cancer cells.Methods:Using MTS / PMS assay,in vitro cell inhibition assay was performed to detect the cell viability of two lung cancer cell lines,NCI-H292 and NCI-H661.PCR was employed to detect the Coxsackie receptor(CAR) expression of cancer cells.The in vivo anti-tumor effect of CRAd and cisplatin was evaluated using a subcutaneous mouse model.Results:The CRAd with cisplatin is superior to the use of cisplatin or CRAd viruse alone on the suppression of lung cancer cell growth.The mechanism of inhibition is associated with the increased CAR expression.Conclusion:The application of CRAd in combination with cisplatin could play a better therapeutic effect on lung cancer cell growth inhibition.
lung cancer adenovirus cisplatin
Liu YaNan Huang Yinghui
China-Japan Union Hospital of Jilin university Jilin, China
国际会议
北京
英文
163-164
2012-10-26（万方平台首次上网日期，不代表论文的发表时间）