Computer-Aided Design and Synthesis of Novel Human Aromatase (CYP19) Inhibitors
In many countries,breast cancer is one of the most common carcinomas among women living.Nearly two-thirds of breast cancers are hormone-dependent and estrogens play a critical role for these cancers cell proliferation.Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment of estrogen receptor positive breast cancer.Inhibitors of this enzyme are potential therapeutics for estrogen dependant breast cancers.However,the current aromatase inhibitors can suffer from drug related toxicity,severer drug resistance and serious drug-drug interactions.Therefore,there is an emergent need to develop novel aromatase inhibitors with higher activity,high selectivity and lower toxicity.
戴玉杰 魏树梅 王海宽 李正军 王强
天津科技大学生物工程学院,天津300457 天津药明康德新药开发有限公司,天津300457
国际会议
南京
英文
137-145
2012-05-13（万方平台首次上网日期，不代表论文的发表时间）