Fabrication and Characterization of Core-shell Structured Composite Nanofibrous Scaffolds by Coaxial Electrospinning

摘要：

　　Biodegradable core-shell structured nanofibrous scaffolds with silk fibroin (SF) and poly(L-lactic acid-co-ε-caprolactone) (P(LLA-CL)) blends as shell and bovine serum albumin (BSA)-containing SF as core were fabricated by coaxial electrospinning.Morphology and microstructure of the nanofibers were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM).The results demonstrated that core-shell structured nanofibers were obtained,furthermore,the nanofibers became greatly uniform and the average diameters were thinner in comparison with only core BSA solution after adding 10-20 w/v% SF in core BSA solution.The 13C NMR clarified the SF conformation transformed from random coil to β-sheet when treated with 75 w/v % ethanol vapor.The mechanical test showed core-shell structured nanofibrous scaffolds possessed good mechanical properties but lower than SF/P(LLA-CL) blended nanofibrous scaffolds.

关键词： SF/P(LLA-CL) blends Core-shell structure Coaxial electrospinning

作者: Qing Ye Kuihua Zhang Shengbao Ke Chaoliang Wang Hongyi Zhang Jianye Wang

作者单位: College of Materials and Textile Engineering, Jiaxing University,Zhejiang 314001, P.R.China

会议类型: 国际会议

会议名称: the 2011 International Conference on Biotechnology, Chemical and Materials Engineering (2011生物,化学与材料工程国际会议(CBCME 2011))

会议地点: 昆明

会议语种:英文

页码: 754-757

在线出版日期: 2011-12-28（万方平台首次上网日期，不代表论文的发表时间）