Synthesis and characterization of Epothilone B molecular imprinted polymers

摘要：

　　Molecular imprinted polymers (MIPs) for antitumor drug Epothilone B have been synthesized with bulk polumerization in order to specifically extract this agent in the present study.MIP was prepared by thermal polymerisation using Epothilone B as template,methacrylic acid as functional monomer,ethylene glycol dimethacrylate (EGDMA) as cross-linking agent.The best synthesis progenic solvent was ultimately determined when the bonding property of the polymer was studied.The selectivity of imprinted polymer on Epothilone B was also studied.The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site.Equilibrium dissociation constant was 3.37 mg/ml,the maximum apparent adsorption was 335 mg/g.

关键词： Molecularly imprinted polymers Epothilone B Molecularly imprinted technique

作者: Guo-li Gong Lin Jia Hui Li

作者单位: College of Life Science and Engineering,Shaanxi University of Science & Technology,Xian,Shaanxi,710 College of Resource and Environment,Shaanxi University of Science and Technology,Xian,Shaanxi,71002

会议类型: 国际会议

会议名称: the Asian Workshop on Polymer Processing 2011(2011高分子加工技术亚洲研讨会(AWPP2011))

会议地点: 青岛

会议语种:英文

页码: 37-41

在线出版日期: 2011-11-04（万方平台首次上网日期，不代表论文的发表时间）