Preparation and Characterization of Coenzyme Q10-loaded Nanostructured Lipid Carriers
The enhancement of stability of light sensitive CoQ10 was achieved by preparation of coenzyme Q10-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH).Well-dissolved lipids of CoQ10 were selected,optimized ratio of emusifiers and lipids were determined for the formulation.Obtained by photon correlation spectroscopy (PCS),the mean particle size of CoQ10-NLC was 112 + 7 nm within 60 days after preparation.In terms of centrifugal stability,results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation.Zeta potential values were from-50 to-55 mV with pH in the range of 6.56-6.72.The concentration of CoQ10-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL.
Coenzyme Q10 High-pressure Homogenization Nanostructured Lipid Carriers
Qiang Xia Jiaying Wu
School of Biological Science&Medical Engineering,Southeast University,Nanjing 210096,China;State Key School of Biological Science&Medical Engineering,Southeast University,Nanjing 210096,China;State Key
国际会议
大理
英文
170-174
2011-08-18（万方平台首次上网日期，不代表论文的发表时间）