Study on Cytotoxicity of Nanoscale Zero Valent Iron Particles
Although small nZNI nanoparticles are useful in various applications,the biosafety of this material needs to be evaluated.In this study,Escherichia coli cells were exposed to 0,112,560,1120 mg/L of nano-Fe0 particles,respectively.Experiments were carried out to examine the activities of lactate dehydrogenase (LDH),cellular superoxide dismutase (SOD),and malondialdehyde (MDA) after exposure to nano-Fe0 for 24h.The activities of LDH and the levels of MDA were significantly increased (P<0.05),respectively.However,the activities of SOD were significantly decreased (P<0.05).A dose dependent increase in lipid peroxidation product (MDA) contents was observed in treatment groups(r=0.945,P<0.05).The result demonstrated that the damage to cell membranes and oxidative stress were mechanisms ofnano-Fe0 ecotoxicity.
Nano-Fe0 Escherichia coli Biochemical parameters Antimicrobial mechanism
Xue Wang Meiying Dong Ling Liu Ying Liu Zhaohui Jin Tielong Li
College of Environmental Science and Engineering,Nankai University,Tianjin 300071,China College of Environmental Science and Engineering,Nankai University,Tianjin 300071,China;Key Laborato College of Environmental Science and Engineering,Nankai University,Tianjin 300071,China;Key Laborato
国际会议
大理
英文
224-228
2011-08-18（万方平台首次上网日期，不代表论文的发表时间）