Freeze-drying and characterization of Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (NLC)

摘要：

　　Vita(m)in A Palmitate-loaded Nanostructured Lipid Carriers (VAP-NLC) were prepared by High Pressure Homogenization (HPH) technique.Trehalose,glucose,mannitol,α-lactin,D-sorbitol,D-maltose monohydrate and sucrose were chosen as the cryoprotectants.Also,the centrifugal stability of VAP-NLC dispersions after diluting different times and the effects of cryoprotectants on the diameter during the freeze-drying process were investigated extensively.Glucose and α-lactin proved to be the most effective in preventing particles aggregation during the VAP-NLC freeze-drying process.The most suitable concentrations were proved to be 5 wt% and 5 wt%,respectively when the dilution times of VAP-NLC dispersions reached 7 or more before freeze-drying.In conclusion,the NLC formulation demonstrated a promising perspective for oral delivery of poorly water-soluble actives in food industry.

关键词： Na(n)ostructured lipid carriers Vitamin A Palmitate Cryoprotectants Lyophilisation High Pressure Homogenization

作者: Qiang Xia Rong Kong

作者单位: School of Biological Science&Medical Engineering,Southeast University,Nanjing 210096,China;State Key School of Biological Science&Medical Engineering,Southeast University,Nanjing 210096,China;State Key

会议类型: 国际会议

会议名称: the international conference on Frontier of Nanoscience and Technology (2011纳米科学与技术国际会议(ICFNST 2011))

会议地点: 大理

会议语种:英文

页码: 365-369

在线出版日期: 2011-08-18（万方平台首次上网日期，不代表论文的发表时间）