Combination of Microemulsion for Topical Deliverying tripterygium wilfordii multiglycoside
(0) The purpose of this study was to explore the potential application of the combination of microemulsion as a topical delivery vehicle in enhancing the absorption and efficacy of tripterygium wilfordii multiglycoside (TWM).Various microemulsion formulations were developed and an optimal microemulsion (TWM-ME),which presented spherical droplets and consisted of RH-40,IPM and water was 27∶ 3.3∶69.7 by weight.It possessd an average droplet size of 23.6 nm,a low viscosity of (3.56±0.12) mm2·s-1 Zeta electric potential was (-5.35±0.42) mV,refractive index was (1.3617±0.0051) nD20,conductivity was (97.6±3.6) μs/cm.Compared to the control solution,TWM-ME provided better skin permeability in vitro.Moreover,TWM-ME has noticeable anti-inflammatory and immune suppression effect.These results indicate that the combination of microemulsion represents an effective vehicle for topical delivery of TWM.
Tripterygium wilfordii multiglycoside microemulsion transdermal-drug delivery system
Xin He Xinghua Zhao wuqing Ou Yang
College Of Traditional Chinese Veterinary Medicine AUH,boling street,Ding Zhou,073000,China Northwest A&F University,22 Xinong Road,Yangling 712100,China
国际会议
大理
英文
881-885
2011-08-18（万方平台首次上网日期，不代表论文的发表时间）