Atomic force microscopy-based investigation on the Elastic Properties of Oligodendrocytes
As the leading killer of human health in the current age,cancer is concerned widely in the medical profession.As the popularizations of atomic force microscopy (AFM) in micro-biology,measuring the mechanical properties of cells by AFM is gradually applied in the diagnosis and treatment of cancer.In this paper,the scanning parameters were optimized and the indentation experiments in different parts of oligodendrocytes were carried out to test the elastic modulus of oligodendrocytes.In order to evaluate the elastic modulus accurately,nine areas on each cell were selected,and for each area,a small matrix of indentation point was made.The results indicated that elastic modulus of the center part of cancer cell is softer than that in the edge,and the one of the normal cell are 3 order of magnitude harder than the cancer cell.
Atomic force microscopy Elastic modulus Oligodendrocytes
Jinghe Wang Miao Yu Li Liu Jie Zhao Yingchun Liang Shen Dong
State Key Laboratory of Robotics and System,Harbin Institute of Technology,Heilongjiang Harbin,China Center for Precision Engineering,Harbin Institute of Technology,Heilongjiang Harbin,China 150001 Center for Precision Engineering,Harbin Institute of Technology,Heilongjiang Harbin,China 150001;The
国际会议
大理
英文
886-890
2011-08-18（万方平台首次上网日期，不代表论文的发表时间）