Positive Darwinian Selection in Gene Evolution
When Charles Darwin proposed the theory of evolution by natural selection,he was concemed with phenotypic evolution.Because all phenotypes have their genetic basis,natural selection indirectly acts on genotypes through its action on phenotypes.In this article,I review the roles of positive Darwinian selection in the evolution of genes,focusing on the work conducted in my laboratory in the last decade.Using real examples,I show that different forms of positive selection can promote amino acid substitutions,cause parallel amino acid changes,increase the rate of insertion/deletion substitutions,accelerate gene loss,and enhance gene expression noise.Although positive selection probably does not account for the majority of changes in DNA sequence evolution,it can and did shape DNA sequence evolution in many different ways and is undoubtedly an important force in molecular evolution.
Positive selection molecular evolution
JianzhiZhang
Department of Ecology and Evolutionary Biology,University of Michigan,Ann Arbor,MI 48109,USA
国际会议
The Darwin 200 Beijing International Conference (纪念达尔文诞辰200周年国际学术会议)
北京
英文
304-325
2009-10-24（万方平台首次上网日期，不代表论文的发表时间）