Titanium Dioxide Nanoparticles Induced cytotoxicity in Rat Retinal Ganglion Cells under Ultraviolet B Irradiation
Titanium dioxide (TiO2) nanoparticles have been widely used in many fields,including biomedicine,cosmetics and environmental engineering.Recently,it was reported that TiO2 nanoparticles could exert genotoxicity on organisms via the generation of reactive oxygen species (ROS).In the present study,we investigated the effect ofTiO2 nanoparticles on RGC-5 cells with or without ultraviolet (UV) B irradiation through MTT assay and determination of hydroxyl radical production.The results demonstrated that TiO2 nanoparticles could efficiently inhibit the growth of RGC-5 cells in the presence of UVB irradiation,whereas there was little impact on target cells in the absence of UV irradiation; UV irradiation could apparently increase the level of hydroxyl radicals in RGC-5 cells and further efficiently inhibit the growth of RGC-5 cells,suggesting that UV irradiation plays an important role in growth inhibition in RGC-5 cells exposed to TiO2 nanoparticles.
Titanium dioxide Nanoparticle Cytotoxicity Retinal Ganglion Cell UV Irradiation
Dadong Guo Hongsheng Bi Qiuxin Wu Daoguang Wang
Yingxiongshan Road 48＃, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Pr Yingxiongshan Road, 48#, Shandong University of Traditional Chinese Medicine, Jinan, China
国际会议
广州
英文
500-503
2012-11-16（万方平台首次上网日期，不代表论文的发表时间）